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the signalling carried either over the DCH or over the HSDPA/HSUPA. For user data, PDCP handles IP header compression. There are several PDCP and RLC entities shown in the gure to indicate the possibility of running parallel services. The BTS-based (fast) scheduling functionality is a MAC layer functionality, and thus there is now a new protocol entity, MAC-hs (hs for high speed), in the BTS. This is shown as part of the user plane protocol architecture in Figure 3.5, which covers HSDPAspeci c additions and their location in the network elements. The RNC retains the MAC-d (d for dedicated), but the only remaining functionality is transport channel switching as all other functionalities, such as scheduling and priority handling, are moved to MAC-hs. It is worth noting that the layer above the MAC layer namely, the RLC layer stays mainly unchanged, but some optimizations for RT services such as VoIP

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Multiple resistance is a phenomenon representing a complex group of cellular processes that are of importance in toxicology and oncology Several mechanisms can account for reduced xenobiotic toxicity observed in various organisms These include impaired uptake, sequestration into a non-target compartment, target alteration, biotransformation and enhanced excretion Among these mechanisms, the importance of enhanced xenobiotic exportation has been recognised as contributing signi cantly to antibiotic and drug resistance in organisms from microbes to man Xenobiotic expulsion, mediated by membrane-associated drug ef ux pumps, can protect cells from a range of toxic compounds and, therefore, may confer single-step multixenobiotic resistance (MXR) (Higgins, 1992) One of the most studied multiple resistance mechanisms is known as multidrug resistance (MDR).

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Finally the need for the speci cation of a General Packet Radio Service (GPRS) was accepted. Different aspects like service requirements, structure and usage of channels, signal1 The views expressed in this section are those of the authors and do not necessarily re ect the views of their af liation entity. 2 Temporary document SMG 200/93.

First described in mammalian cancer cell lines, this mechanism is related to the expression of a membrane permeability glycoprotein (Pgp) that confers the ability to lower the intracellular concentration of many different structurally and functionally unrelated toxic compounds below their toxic level (Gottesman & Pastan, 1993) This phenomenon is a major problem in cancer chemotherapy and tumours found to express the P-glycoprotein have been shown to have a poor prognosis (Chan et al, 1990) Nevertheless, multiple resistance is not restricted to cancer cell lines A related phenomenon occurs in tissues of a wide range of natural species in order to prevent xenobiotic accumulation by transporting toxic xenobiotics or endogenous metabolites out of the cell (Thiebaut et al, 1987; Ouellette & Borst, 1991; Wu et al, 1991) Marine organisms possess one or several proteins related to this transport system.

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Studies using radiolabelled, photolabelled and uorescent compounds have shown that cells expressing this protein share some similar pharmacological behaviour with MDRpositive cancer cells (Kurelec, 1992; Holland-Toomey & Epel, 1993; Cornwall et al, 1995) The proposed role for this MXR mechanism in these marine animals is to serve as a defence system against environmental xenobiotics (Kurelec, 1992; Kurelec et al, 1996) In accordance with this hypothesis, some environmental xenobiotics, mainly hydrophobic pesticides, have been reported to interact with the mussel MXR-protein (Cornwall et al, 1995; Galgani et al, 1996) and differential expression levels of the MXR-protein have been found in mussels living in polluted and unpolluted waters (Minier et al, 1993)..

Replaying is difficult to prevent. The obvious solution is to tightly control the flow of network packets. This reinforces the concern we raised earlier about separating private from public networks, which is achieved by firewalls that we will discuss below.

Section I contained 25 multiple choice items examining the defendant s vocabulary and concepts. Section II contained 15 multiple choice items to assess the defendant s ability to assist in his/her own defence and to understand proceedings in court. Section III contained 10 open-ended questions examining the defendant s ability to relate factual events and understand the charges.

Copyright Thomas J. Lucier 2005. To customize this document, download it to your hard drive from Thomas J. Lucier s web site at www.thomaslucier.com/optionforms.html. The document can then be opened, edited, and printed using Microsoft Word or another popular word processing application.

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