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149 Xu, Y C; Shen, J H; Luo, X M; Silman, I; Sussman, J L; Chen, K X; Jiang, H L How does huperzine A enter and leave the binding gorge of acetylcholinesterase Steered molecular dynamics simulations J Am Chem Soc, 2003, 125(37): 11340 11349 150 Kaur, J; Zhang, M Q Molecular modelling and QSAR of reversible acetylcholinesterase inhibitors Curr Med Chem, 2000, 7(3): 273 294 151 Camps, P; Cusack, B; Mallender, W D; El Achab, R; Morral, J; Munoz-Torrero, D; Rosenberry, T L Huprine X is a novel high-af nity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer s disease Mol Pharmacol, 2000, 57(2): 409 417 152 Camps, P; El Achab, R; Morral, J; Munoz-Torrero, D; Badia, A; Banos, J E; Vivas, N M.

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; Barril, X; Orozco, M; Luque, F J New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer s disease J Med Chem, 2000, 43(24): 4657 4666 153 Camps, P; Gomez, E; Munoz-Torrero, D; Arno, M On the regioselectivity of the Friedlander reaction leading to huprines: stereospeci c acid-promoted isomerization of syn-huprines to their anti-regioisomers Tetrahedron-Asymmetry, 2001, 12(20): 2909 2914 154 Ros, E; Aleu, J; De Aranda, I G; Munoz-Torrero, D; Camps, P; Badia, A; Marsal, J; Solsona, C The pharmacology of novel acetylcholinesterase inhibitors ( )-huprines Y and X on the Torpedo electric organ Eur J Pharmacol, 2001, 421(2): 77 84 155 Camps, P; Gomez, E; Munoz-Torrero, D; Badia, A; Vivas, N M; Barril, X; Orozco, M; Luque, F J.

Lower in power than the larger studio units, speedlights offer portability and ease of use unmatched in any type of lighting system Speedlights are also the least expensive way of creating a photographic lighting kit 6 deals speci cally with details on working with speedlights because they are the most popular and accessible system for most photographers This section brie y looks at some of the features available to you when working with this type of ash unit Through-the-Lens (TTL) metering Today s most advanced small ash metering system uses pre ashes and ash-metering algorithms to determine the proper ash exposure The TTL system reads information from all metering zones before and after the pre ash After the pre ash, areas with little change in brightness are then weighted for ash metering.

This is done to avoid highly re ective surfaces such as glass or chrome or other overly bright areas from creating a false reading, thereby causing underexposure When you use certain lenses, distance information is also reported back to the ash and entered into the algorithm Wireless control Many of the latest speedlights allow you to re ashes wirelessly When using this feature you need to have either a ash set as a master/ commander unit or an optical wireless transmitter tted on your camera s hot shoe A master unit res a pre ash, which then transmits information back and forth between the camera and the ash The master unit can control multiple speedlights wirelessly, allowing for more creative lighting setups This enables you to control up to three groups of speedlights in TTL or Manual mode.

Synthesis in vitro pharmacology and molecular modeling of synhuprines as acetylcholinesterase inhibitors J Med Chem, 2001, 44(26): 4733 4736 156 Carlier, P R; Han, Y F; Chow, E S H; Li, C P L; Wang, H; Lieu, T X; Wong, H S; Pang, Y P Evaluation of short-tether bis-THA AChE inhibitors A further test of the dual binding site hypothesis Bioorg Med Chem, 1999, 7(2): 351 357 157 Harel, M; Schalk, I; Ehret-Sabatier, L; Bouet, F; Goeldner, M; Hirth, C; Axelsen, P H; Silman, I; Sussman, J L Quaternary ligand binding to aromatic residues in the active-site gorge of acetylcholinesterase P Natl Acad Sci USA, 1993, 90(19): 9031 9035 158 Dvir, H; Wong, D M; Harel, M; Barril, X; Orozco, M; Luque, F J; Munoz-Torrero, D.

8.5 A surfer rides a late-afternoon wave in Hawaii. Notice how the fast shutter speed freezes the water droplets and the spray in midair looks sharp. Sandy or moist environments like this can wreak havoc on a camera s delicate electronics and optics, so keep a soft white towel handy to remove dust and to keep the camera cool by re ecting heat when not in use. Exposure: ISO 200, f/4, 1/800 second.

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