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Topical, Ophthalmic, and Otic Preparations Clarity, homogeneity, pH, resuspendability (for lotions), consistency, viscosity, microbial bioburden, and water loss should be tested. For ophthalmic and otic products additional attributes should include sterility, particulate matter, and extractables. Suppositories Softening range, dissolution at 37 C. Transdermal Patches In vitro release rates, leakage, microbial bioburden/ sterility, and peel and adhesive forces. Metered-Dose Inhalers and Nasal Aerosols Content uniformity, aerodynamic particle size distribution, microscopic evaluation, water content, leak rate, microbial bioburden, valve delivery, extractables, leachables from plastic and elastomeric components. Nasal Sprays Clarity, microbial bioburden, pH, particulate matter, unit spray medication content uniformity, droplet and/or particle size distribution, weight loss, pump delivery, microscopic evaluation of suspensions, particulate matter, extractables, leachables from plastic and elastomeric components of container closure and pump. Small-Volume Parenterals Color, clarity of solutions, particulate matter, pH, sterility, endotoxins. Powders for injection solutions include clarity, color, reconstitution time and water content, pH, sterility, endotoxins/pyrogens, and particulate matter. Suspensions for injection should include additional particle size distribution, redispersability, and rheological properties. Emulsion for injection should include phase separation, viscosity, mean size, and distribution of dispersed globules. Large-Volume Parenterals Color, clarity, particulate matter, pH, sterility, endotoxin/pyrogen, and volume.

You can also create your own button definition from scratch. Follow these steps: 1. In the Customizations In pane, double-click the Toolbars item and choose the toolbar that you want to work with.

Half-power beamwidth (HPB W): The angle spanned by the intensity region for which Umax/2 5 U 5 Urn,,. The HPBW is associated with the ability of an antenna to direct a beam. The HPBW is often referred to as the 3 dB beamwidth for obvious reasons. First null beamwidth (FNB W): The angle spanned by the main lobe. The FNBW is associated with the ability of an antenna to reject interference.

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had described the association of hypertension, diabetes and gout during the 1920s (Kylin, 1923). Other notable contributions include the demonstration in 1963 by Philip Randle, Nick Hales and colleagues in Oxford that high free fatty acid levels could interfere with glucose utilization (thus effectively counteracting the action of insulin) through the Randle or glucose-fatty acid cycle (Randle et al., 1963). Other comorbidities of obesity have been recognized since antiquity. Associated respiratory problems possibly reminiscent of the obesity hypoventilation syndrome were described as long ago as the Greco-Roman era (Kryger, 1983). The rst clear medical report of sleep apnoea was apparently that of Russell in 1866. The latter was published some 30 years after Charles Dickens novel Pickwick Papers, which features a fat boy, Joe, who frequently falls asleep hence the alternative name of Pickwickian syndrome that William Osler applied to the obesity hypoventilation syndrome. Fatty liver, long recognized as a consequence of overfeeding in geese ( foie gras) and a feature of human obesity, was

Figure 2-27: The Index Selection window opens after you choose Edit Search Select Indexes. From this window you can add or remove different index files.

The nodal shape functions on the reference domain K , are split into three groups according to the different types of nodes introduced above.

Imagine that you ve downloaded a package named foobar-1.0-1.i386.rpm and you re now ready to install it. In this example, foobar is the name of the package, 1.0-1 are version numbers, and i386 is the architecture (in this case Intel 386, meaning PC-type processors). You can install an RPM package from any directory, but it s best to keep the packages you ve downloaded in a central location. You can use an already existing directory, or you can create one just for this purpose. To install this file to a directory called /RPM, for example, give the su command to become root, and then give the following command:

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